NSC 135130

• CAT Number: I040500
• CAS Number: 24164-06-5
• Molecular Formula: C12H23NO4
• Molecular Weight: 245.32
• Purity: ≥95%
• Synonyms: methyl (2S)-3-methyl-2-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]butanoate
• InChI: InChI=1S/C12H23NO4/c1-8(2)9(10(14)16-7)13(6)11(15)17-12(3,4)5/h8-9H,1-7H3/t9-/m0/s1
• InChIKey: JHELVJNRWQYMIA-VIFPVBQESA-N
• SMILES: CC(C)C(C(=O)OC)N(C)C(=O)OC(C)(C)C

NSC 135130 (CAT: I040500) is a BOC-protected linker designed for use in the synthesis of antibody-drug conjugates (ADCs). Its structure allows for efficient conjugation to tubulin-targeting cytotoxic agents, facilitating the development of targeted therapeutics with improved selectivity and reduced systemic toxicity. The BOC (tert-butoxycarbonyl) protection enhances chemical stability and enables controlled deprotection during synthesis. NSC 135130 serves as a versatile intermediate for creating drug-linker conjugates in preclinical ADC development, particularly those leveraging microtubule-disrupting payloads. Supplied in high purity, this compound supports research in bioconjugation, linker optimization, and the design of next-generation targeted cancer therapies.