NSC 107512

• CAT Number: I045249
• CAS Number: 22242-89-3
• Molecular Formula: C12H16N6O5
• Molecular Weight: 324.29
• Purity: ≥95%
• Synonyms: 4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-N’-hydroxypyrrolo[2,3-d]pyrimidine-5-carboximidamide
• IUPAC Name: 4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-N'-hydroxypyrrolo[2,3-d]pyrimidine-5-carboximidamide
• InChI: InChI=1S/C12H16N6O5/c13-9(17-22)4-1-18(11-6(4)10(14)15-3-16-11)12-8(21)7(20)5(2-19)23-12/h1,3,5,7-8,12,19-22H,2H2,(H2,13,17)(H2,14,15,16)/t5-,7-,8-,12-/m1/s1
• InChIKey: UJSNJRHHJZOXPZ-JTFADIMSSA-N
• SMILES: C1=C(C2=C(N=CN=C2N1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N)/C(=N/O)/N

NSC 107512（Cat No.:I045249）is a small-molecule inhibitor targeting DNA topoisomerase II, an essential enzyme that modulates DNA topology during replication, transcription, and chromosome segregation. By stabilizing the topoisomerase II–DNA cleavage complex, NSC 107512 induces double-strand breaks, leading to DNA damage and apoptosis, particularly in rapidly dividing cells. This compound has been explored in cancer research for its ability to disrupt tumor cell proliferation. Its potency and mechanism make it a valuable tool for studying DNA damage responses, topoisomerase biology, and the development of chemotherapeutic strategies targeting DNA topology regulation.