NS3861 fumarate

• CAT Number: I011035
• CAS Number: 216853-60-0
• Molecular Formula: C16H18BrNO4S
• Molecular Weight: 400.29
• Purity: ≥95%
• Synonyms: 3-(3-bromothiophen-2-yl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene;(E)-but-2-enedioic acid
• InChI: InChI=1S/C12H14BrNS.C4H4O4/c1-14-9-2-3-10(14)7-8(6-9)12-11(13)4-5-15-12;5-3(6)1-2-4(7)8/h4-6,9-10H,2-3,7H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
• InChIKey: KXBSQPLWTVQFGJ-WLHGVMLRSA-N
• SMILES: CN1C2CCC1C=C(C2)C3=C(C=CS3)Br.C(=CC(=O)O)C(=O)O

NS3861 fumarate (Cat No.: I011035) is a stabilized salt form of NS3861, a small-molecule modulator of voltage-gated sodium channels involved in neuronal excitability. By influencing sodium channel activity, it serves as a valuable research tool for studying mechanisms underlying epilepsy, neuropathic pain, and other excitability-related neurological disorders. The fumarate form improves solubility and handling in laboratory settings. Although not approved for therapeutic use, NS3861 fumarate is widely applied in neuropharmacology research to explore ion channel function and potential strategies for drug discovery.

Reference

[1]. Kasper Harpsøe, et al. Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors. J Biol Chem. 2013 Jan 25;288(4):2559-70.
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