For research use only. Not for therapeutic Use.
NS383（Cat No.:I033542）is a selective small-molecule inhibitor of transforming growth factor-beta receptor I (TGF-βRI/ALK5), a serine/threonine kinase involved in TGF-β signaling, which regulates cell proliferation, differentiation, immune response, and fibrosis. By inhibiting ALK5 activity, NS383 blocks Smad2/3 phosphorylation, thereby suppressing downstream transcriptional activity associated with tumor progression, fibrotic diseases, and immune evasion. NS383 is widely used in oncology, fibrosis, and immunology research to explore TGF-β pathway modulation and its therapeutic implications. It serves as a valuable tool in studying tumor microenvironment remodeling and anti-fibrotic strategies in preclinical disease models.
| CAS Number | 309711-59-9 |
| Synonyms | 8-ethyl-3-nitroso-5-phenyl-1,6,7,9-tetrahydropyrrolo[3,2-h]isoquinolin-2-ol |
| Molecular Formula | C19H19N3O2 |
| Purity | ≥95% |
| IUPAC Name | 8-ethyl-3-nitroso-5-phenyl-1,6,7,9-tetrahydropyrrolo[3,2-h]isoquinolin-2-ol |
| InChI | InChI=1S/C19H19N3O2/c1-2-22-9-8-13-14(12-6-4-3-5-7-12)10-15-17(16(13)11-22)20-19(23)18(15)21-24/h3-7,10,20,23H,2,8-9,11H2,1H3 |
| InChIKey | OZVZKENYKWSYBC-UHFFFAOYSA-N |
| SMILES | CCN1CCC2=C(C=C3C(=C2C1)NC(=C3N=O)O)C4=CC=CC=C4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
