For research use only. Not for therapeutic Use.
NRX-2663（Cat No.:I045285）is an investigational, orally bioavailable small-molecule compound designed to modulate GABA-A receptor activity with high selectivity. It acts as a positive allosteric modulator, enhancing inhibitory neurotransmission to restore balance in neural circuits implicated in neuropsychiatric and neurological disorders. Preclinical data suggest potential applications in treating anxiety, depression, and seizure-related conditions, offering rapid onset and reduced side-effect liability compared to traditional agents. With favorable pharmacokinetics and central nervous system penetration, NRX-2663 is being explored as a next-generation therapeutic candidate to improve efficacy and tolerability in disorders involving impaired inhibitory neurotransmission.
| CAS Number | 2763260-34-8 |
| Synonyms | 3-[[2-oxo-4-phenoxy-6-(trifluoromethyl)-1H-pyridine-3-carbonyl]amino]benzoic acid |
| Molecular Formula | C20H13F3N2O5 |
| Purity | ≥95% |
| IUPAC Name | 3-[[2-oxo-4-phenoxy-6-(trifluoromethyl)-1H-pyridine-3-carbonyl]amino]benzoic acid |
| InChI | InChI=1S/C20H13F3N2O5/c21-20(22,23)15-10-14(30-13-7-2-1-3-8-13)16(18(27)25-15)17(26)24-12-6-4-5-11(9-12)19(28)29/h1-10H,(H,24,26)(H,25,27)(H,28,29) |
| InChIKey | QMARDTCIJVODCK-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)OC2=C(C(=O)NC(=C2)C(F)(F)F)C(=O)NC3=CC=CC(=C3)C(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
