For research use only. Not for therapeutic Use.
NRX-252114 (Cat No.: I045620) is a potent, selective small-molecule inhibitor of the checkpoint kinase 1 (CHK1), a key regulator of the DNA damage response and cell cycle control. By blocking CHK1 activity, NRX-252114 disrupts homologous recombination repair, sensitizing tumor cells to replication stress and DNA-damaging agents such as chemotherapy or PARP inhibitors. It has been investigated in oncology research as a candidate for combination cancer therapies. NRX-252114 provides a valuable chemical probe for studying DNA repair mechanisms, genome stability, and therapeutic strategies targeting CHK1.
| CAS Number | 2763260-39-3 |
| Synonyms | 2-[4-(2,6-dichlorophenyl)sulfanyl-2-oxo-6-(trifluoromethyl)-1H-pyridine-3-carbonyl]-1,3-dihydroisoindole-4-carbonitrile |
| Molecular Formula | C22H12Cl2F3N3O2S |
| Purity | ≥95% |
| InChI | InChI=1S/C22H12Cl2F3N3O2S/c23-14-5-2-6-15(24)19(14)33-16-7-17(22(25,26)27)29-20(31)18(16)21(32)30-9-12-4-1-3-11(8-28)13(12)10-30/h1-7H,9-10H2,(H,29,31) |
| InChIKey | BMQXGPBUQGPLOV-UHFFFAOYSA-N |
| SMILES | C1C2=C(CN1C(=O)C3=C(C=C(NC3=O)C(F)(F)F)SC4=C(C=CC=C4Cl)Cl)C(=CC=C2)C#N |
| Reference | [1]. Kyle R Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10(1):1402. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
