NQTrp

For research use only. Not for therapeutic Use.

  • CAT Number: I011187
  • CAS Number: 185351-19-3
  • Molecular Formula: C21H16N2O4
  • Molecular Weight: 360.36
  • Purity: ≥95%
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NQTrp (Cat No.:I011187) is a synthetic small molecule designed to inhibit the aggregation of amyloidogenic proteins, particularly amyloid-β (Aβ) and α-synuclein, which are implicated in Alzheimer’s and Parkinson’s diseases, respectively. NQTrp binds to misfolded protein intermediates, preventing fibril formation and promoting non-toxic aggregation pathways. It has shown neuroprotective effects in various in vitro and in vivo models by reducing amyloid toxicity, oxidative stress, and inflammation. As a promising lead compound, NQTrp is widely used in neurodegenerative disease research focused on therapeutic strategies targeting protein misfolding and aggregation.


CAS Number 185351-19-3
Synonyms

(2S)-2-[(1,4-dioxonaphthalen-2-yl)amino]-3-(1H-indol-3-yl)propanoic acid

Molecular Formula C21H16N2O4
Purity ≥95%
IUPAC Name (2S)-2-[(1,4-dioxonaphthalen-2-yl)amino]-3-(1H-indol-3-yl)propanoic acid
InChI InChI=1S/C21H16N2O4/c24-19-10-17(20(25)15-7-2-1-6-14(15)19)23-18(21(26)27)9-12-11-22-16-8-4-3-5-13(12)16/h1-8,10-11,18,22-23H,9H2,(H,26,27)/t18-/m0/s1
InChIKey DZZUYZXINNHEGM-SFHVURJKSA-N
SMILES C1=CC=C2C(=C1)C(=O)C=C(C2=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)O
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