For research use only. Not for therapeutic Use.
NPAS3-IN-1(CAT: I040638) is a potent small-molecule inhibitor that selectively disrupts the heterodimerization of NPAS3 with ARNT (aryl hydrocarbon receptor nuclear translocator), a critical interaction for NPAS3-mediated transcriptional activity. By blocking this protein–protein interaction at the cellular level, NPAS3-IN-1 modulates downstream gene expression linked to neuronal development, neurogenesis, and psychiatric disorders. This compound serves as a valuable tool for studying NPAS3 signaling pathways, exploring its role in central nervous system function, and assessing its therapeutic potential in neuropsychiatric and neurodevelopmental disorders. NPAS3-IN-1 is ideal for mechanistic studies involving bHLH-PAS transcription factors and transcriptional regulation.
| CAS Number | 2207-44-5 |
| Synonyms | 2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3-benzothiazole |
| Molecular Formula | C10H5N3O2S3 |
| Purity | ≥95% |
| IUPAC Name | 2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3-benzothiazole |
| InChI | InChI=1S/C10H5N3O2S3/c14-13(15)8-5-11-9(17-8)18-10-12-6-3-1-2-4-7(6)16-10/h1-5H |
| InChIKey | UHBFMJAKLZGVDS-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C(=C1)N=C(S2)SC3=NC=C(S3)[N+](=O)[O-] |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
