NP213 TFA

• CAT Number: I045897
• Molecular Formula: C44H85F3N28O9
• Molecular Weight: 1207.32
• Purity: ≥95%
• Synonyms: 2-[3-[(2S,5S,8S,11S,14S,17S,20S)-5,8,11,14,17,20-hexakis[3-(diaminomethylideneamino)propyl]-3,6,9,12,15,18,21-heptaoxo-1,4,7,10,13,16,19-heptazacyclohenicos-2-yl]propyl]guanidine;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C42H84N28O7.C2HF3O2/c43-36(44)57-15-1-8-22-29(71)65-24(10-3-17-59-38(47)48)31(73)67-26(12-5-19-61-40(51)52)33(75)69-28(14-7-21-63-42(55)56)35(77)70-27(13-6-20-62-41(53)54)34(76)68-25(11-4-18-60-39(49)50)32(74)66-23(30(72)64-22)9-2-16-58-37(45)46;3-2(4,5)1(6)7/h22-28H,1-21H2,(H,64,72)(H,65,71)(H,66,74)(H,67,73)(H,68,76)(H,69,75)(H,70,77)(H4,43,44,57)(H4,45,46,58)(H4,47,48,59)(H4,49,50,60)(H4,51,52,61)(H4,53,54,62)(H4,55,56,63);(H,6,7)/t22-,23-,24-,25-,26-,27-,28-;/m0./s1
• InChIKey: RAWZYRRHFHWWGX-UZTLYUDCSA-N
• SMILES: C(C[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCCN=C(N)N)CCCN=C(N)N)CCCN=C(N)N)CCCN=C(N)N)CCCN=C(N)N)CCCN=C(N)N)CN=C(N)N.C(=O)(C(F)(F)F)O

NP213 TFA (Cat No.:I045897) is a synthetic antifungal peptide derived from naturally occurring host defense peptides. It exhibits potent activity against dermatophytes, the primary pathogens causing onychomycosis and other superficial fungal infections. NP213 acts by disrupting fungal cell membranes, leading to rapid killing with low potential for resistance development. Supplied as the trifluoroacetate (TFA) salt, it offers stability and solubility for research and clinical formulation. NP213 TFA is under investigation as a topical therapy for nail infections, providing a novel, non-systemic approach to antifungal treatment.