NOTA-FAPI-4（Cat No.:I033480）, an analog of FAPI-4, is a potent inhibitor of fibroblast activation protein (FAP). It finds utility in the diagnosis and treatment of diseases characterized by the overexpression of FAP. As a PET tracer, NOTA-FAPI-4 enables the detection of diseases or disorders associated with FAP. This includes various types of cancers where FAP is upregulated. By specifically targeting FAP, NOTA-FAPI-4 allows for non-invasive imaging and facilitates the identification and monitoring of FAP-related conditions for improved diagnosis and personalized treatment strategies.
| Catalog Number | I033480 |
| CAS Number | 2374782-03-1 |
| Synonyms | NOTA-FAPI-4; |
| Molecular Formula | C36H47F2N9O8 |
| Purity | 98 |
| Solubility | To be determined |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | (S)-2,2'-(7-(2-(4-(3-((4-((2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamoyl)quinolin-6-yl)oxy)propyl)piperazin-1-yl)-2-oxoethyl)-1,4,7-triazonane-1,4-diyl)diacetic acid |
| InChI | InChI=1S/C36H47F2N9O8/c37-36(38)19-26(20-39)47(25-36)31(48)21-41-35(54)28-4-5-40-30-3-2-27(18-29(28)30)55-17-1-6-42-13-15-46(16-14-42)32(49)22-43-7-9-44(23-33(50)51)11-12-45(10-8-43)24-34(52)53/h2-5,18,26H,1,6-17,19,21-25H2,(H,41,54)(H,50,51)(H,52,53)/t26-/m0/s1 |
| InChIKey | XQARGGQZFNOLDH-SANMLTNESA-N |
| SMILES | O=C(C1=CC=NC2=CC=C(C=C21)OCCCN3CCN(CC3)C(CN4CCN(CCN(CC4)CC(O)=O)CC(O)=O)=O)NCC(N5CC(F)(C[C@@]5([H])C#N)F)=O |
