• CAT Number: I033426
  • CAS Number: 158563-45-2
  • Molecular Formula: C61H87N15O9S
  • Molecular Weight: 1206.52
  • Purity: 98%
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Nonapeptide-1 (CAT: I033426), also known as Melanostatine™ 5, is a proprietary peptide initially recognized for its antimicrobial properties. Through animal studies, it has been revealed that nonapeptide-1 possesses the ability to hinder the synthesis of melanin, making it a promising candidate for addressing specific skin conditions. Preclinical research indicates that nonapeptide-1 has the potential to effectively diminish the production of melanin, leading to a significant reduction in skin pigmentation.

Catalog Number I033426
CAS Number 158563-45-2

Nonapeptide-1; Nonapeptide 1; Nonapeptide1; Met-pro-phe-arg-trp-phe-lys-pro-val; White 05; Melanostatine 5; Melanostatine-5

Molecular Formula


Purity 98
Solubility Soluble in DMSO
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name (S)-1-(L-methionyl)-N-((R)-1-(((S)-1-(((R)-1-(((S)-1-(((S)-6-amino-1-((S)-2-(((S)-1-amino-3-methyl-1-oxobutan-2-yl)carbamoyl)pyrrolidin-1-yl)-1-oxohexan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide
InChI InChI=1S/C61H87N15O9S/c1-37(2)51(52(64)77)74-58(83)50-26-16-31-76(50)60(85)45(23-12-13-28-62)70-55(80)46(33-38-17-6-4-7-18-38)71-56(81)48(35-40-36-68-43-22-11-10-21-41(40)43)72-53(78)44(24-14-29-67-61(65)66)69-54(79)47(34-39-19-8-5-9-20-39)73-57(82)49-25-15-30-75(49)59(84)42(63)27-32-86-3/h4-11,17-22,36-37,42,44-51,68H,12-16,23-35,62-63H2,1-3H3,(H2,64,77)(H,69,79)(H,70,80)(H,71,81)(H,72,78)(H,73,82)(H,74,83)(H4,65,66,67)/t42-,44-,45-,46-,47+,48+,49-,50-,51-/m0/s1
SMILES CC(C)[C@@H](C(N)=O)NC([C@H]1N(C([C@H](CCCCN)NC([C@H](CC2=CC=CC=C2)NC([C@@H](CC3=CNC4=C3C=CC=C4)NC([C@H](CCCNC(N)=N)NC([C@@H](CC5=CC=CC=C5)NC([C@H]6N(C([C@H](CCSC)N)=O)CCC6)=O)=O)=O)=O)=O)=O)CCC1)=O

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4: Zabłocka A, Mitkiewicz M, Macała J, Janusz M. Neurotrophic Activity of Cultured Cell Line U87 is Up-Regulated by Proline-Rich Polypeptide Complex and Its Constituent Nonapeptide. Cell Mol Neurobiol. 2015 Oct;35(7):977-86. doi: 10.1007/s10571-015-0192-8. Epub 2015 Apr 5. PubMed PMID: 25841889; PubMed Central PMCID: PMC4572042.
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6: Tomaszycki ML, Richardson KK, Mann KJ. Sex and pairing status explain variations in the activation of nonapeptide receptors in song and motivation regions. Behav Neurosci. 2016 Oct;130(5):479-89. doi: 10.1037/bne0000159. Epub 2016 Aug 8. PubMed PMID: 27504854.
7: Baran NM, Sklar NC, Adkins-Regan E. Developmental effects of vasotocin and nonapeptide receptors on early social attachment and affiliative behavior in the zebra finch. Horm Behav. 2016 Feb;78:20-31. doi: 10.1016/j.yhbeh.2015.10.005. Epub 2015 Oct 23. PubMed PMID: 26476409; PubMed Central PMCID: PMC4718777.
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9: Grenács Á, Sóvágó I. Copper(II), nickel(II) and zinc(II) complexes of the N-terminal nonapeptide fragment of amyloid-β and its derivatives. J Inorg Biochem. 2014 Oct;139:49-56. doi: 10.1016/j.jinorgbio.2014.06.001. Epub 2014 Jun 10. PubMed PMID: 24973554.
10: Orcel U, De Poli M, De Zotti M, Clayden J. The N-terminal nonapeptide of cephaibols A and C: a naturally occurring example of mismatched helical screw-sense control. Chemistry. 2013 Nov 25;19(48):16357-65. doi: 10.1002/chem.201302648. Epub 2013 Oct 9. PubMed PMID: 24123376.
11: Goodson JL, Kelly AM, Kingsbury MA. Evolving nonapeptide mechanisms of gregariousness and social diversity in birds. Horm Behav. 2012 Mar;61(3):239-50. doi: 10.1016/j.yhbeh.2012.01.005. Epub 2012 Jan 13. Review. PubMed PMID: 22269661; PubMed Central PMCID: PMC3312996.
12: Lowrey EM, Tomaszycki ML. The formation and maintenance of social relationships increases nonapeptide mRNA in zebra finches of both sexes. Behav Neurosci. 2014 Feb;128(1):61-70. doi: 10.1037/a0035416. PubMed PMID: 24512066.
13: Asami T, Nishizawa N, Matsui H, Takatsu Y, Suzuki A, Kiba A, Terada M, Nishibori K, Nakayama M, Ban J, Matsumoto S, Tarui N, Ikeda Y, Yamaguchi M, Kusaka M, Ohtaki T, Kitada C. Physicochemically and pharmacokinetically stable nonapeptide KISS1 receptor agonists with highly potent testosterone-suppressive activity. J Med Chem. 2014 Jul 24;57(14):6105-15. doi: 10.1021/jm5005489. Epub 2014 Jul 7. PubMed PMID: 24918545.
14: Gu C, Liu L, He Y, Jiang J, Yang Z, Wu Q. The binding characteristics of a cyclic nonapeptide, c(CGRRAGGSC), in LNCaP human prostate cancer cells. Oncol Lett. 2012 Sep;4(3):443-449. Epub 2012 Jun 21. PubMed PMID: 22970042; PubMed Central PMCID: PMC3439175.
15: Zhang JY, Deng XM, Li FP, Wang L, Huang QY, Zhang CC, Chen WL. RNase E forms a complex with polynucleotide phosphorylase in cyanobacteria via a cyanobacterial-specific nonapeptide in the noncatalytic region. RNA. 2014 Apr;20(4):568-79. doi: 10.1261/rna.043513.113. Epub 2014 Feb 21. PubMed PMID: 24563514; PubMed Central PMCID: PMC3964918.
16: Baran NM, Tomaszycki ML, Adkins-Regan E. Early Life Manipulations of the Nonapeptide System Alter Pair Maintenance Behaviors and Neural Activity in Adult Male Zebra Finches. Front Behav Neurosci. 2016 Mar 29;10:58. doi: 10.3389/fnbeh.2016.00058. eCollection 2016. PubMed PMID: 27065824; PubMed Central PMCID: PMC4810809.
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19: Klatt JD, Goodson JL. Sex-specific activity and function of hypothalamic nonapeptide neurons during nest-building in zebra finches. Horm Behav. 2013 Nov;64(5):818-24. doi: 10.1016/j.yhbeh.2013.10.001. Epub 2013 Oct 11. PubMed PMID: 24126135.
20: Asami T, Nishizawa N, Matsui H, Nishibori K, Ishibashi Y, Horikoshi Y, Nakayama M, Matsumoto S, Tarui N, Yamaguchi M, Matsumoto H, Ohtaki T, Kitada C. Design, synthesis, and biological evaluation of novel investigational nonapeptide KISS1R agonists with testosterone-suppressive activity. J Med Chem. 2013 Nov 14;56(21):8298-307. doi: 10.1021/jm401056w. Epub 2013 Oct 17. PubMed PMID: 24047141.

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