N,O-Bis(trimethylsilyl)trifluoroacetamide

• CAT Number: R040791
• CAS Number: 25561-30-2
• Molecular Formula: C₈H₁₈F₃NOSi₂
• Molecular Weight: 257.4
• Purity: ≥95%
• Synonyms: 2,2,2-trifluoro-N-(trimethylsilyl)ethanimidic Acid Trimethylsilyl Ester?2,2,2-trifluoro-N-(trimethylsilyl)acetimidic Acid Trimethylsilyl Ester; 2,2,2-trifluoro-N-(trimethylsilyl)acetimidate Trimethylsilanol; 2,2,2-Trifluoro-N,O-bis(trimethylsilyl)ace
• Storage: -20°C
• IUPAC Name: trimethylsilyl 2,2,2-trifluoro-N-trimethylsilylethanimidate
• InChI: InChI=1S/C8H18F3NOSi2/c1-14(2,3)12-7(8(9,10)11)13-15(4,5)6/h1-6H3
• InChIKey: XCOBLONWWXQEBS-UHFFFAOYSA-N
• SMILES: C[Si](C)(C)N=C(C(F)(F)F)O[Si](C)(C)C

N,O-Bis(trimethylsilyl)trifluoroacetamide (Cat No.: R040791) is a widely used silylating reagent in analytical and organic chemistry, particularly for gas chromatography (GC) and mass spectrometry (MS) sample preparation. It reacts with compounds containing active hydrogen atoms—such as alcohols, amines, and carboxylic acids—by replacing them with trimethylsilyl (TMS) groups, thereby increasing volatility and thermal stability. The trifluoroacetamide backbone enhances reactivity and minimizes byproducts. BSTFA is essential for derivatizing polar analytes to improve chromatographic performance. For laboratory research and analytical use under controlled conditions.