N,N'-Di(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid monohydrochloride hydrate

  • CAT Number: M144091
  • CAS Number: 35369-53-0
  • Molecular Formula: C20H24N2O6·HCl·XH2O
  • Molecular Weight: 424.89
  • Purity: ≥95%
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<span style="color:#000000;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:12px;">N,N&#39;-Di(2-hydroxybenzyl)ethylenediamine-N,N&#39;-diacetic acid monohydrochloride hydrate (CAS&nbsp;35369-53-0), also known as HBED,&nbsp;<span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">is an iron chelator and hydroxyl radical inhibitor.</span><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">HBED is described to facilitate Fe(II) oxidation and to block O</span><sub style="box-sizing: border-box; line-height: 1; color: rgb(51, 51, 51); font-family: openSans, arial, sans-serif; font-variant-ligatures: normal; orphans: 2; widows: 2;">2</sub><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">(.-)-induced reduction of Fe(III), consequently blocking the Fe-mediated formation of hydroxyl radicals. HBED has been utilized as a tool for studying the involvement of hydroxyl radicals in cellular processes. HBED has specifically demonstrated to inhibit H</span><sub style="box-sizing: border-box; line-height: 1; color: rgb(51, 51, 51); font-family: openSans, arial, sans-serif; font-variant-ligatures: normal; orphans: 2; widows: 2;">2</sub><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">O</span><sub style="box-sizing: border-box; line-height: 1; color: rgb(51, 51, 51); font-family: openSans, arial, sans-serif; font-variant-ligatures: normal; orphans: 2; widows: 2;">2</sub><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">-induced apoptosis in neutrophils, suggesting participation of hydroxyl radicals in the mediation of neutrophilic apoptosis.</span></span></span></span>

Catalog Number M144091
CAS Number 35369-53-0
Synonyms

HBED

Molecular Formula

C20H24N2O6·HCl·XH2O

Purity 95%
Storage Store at 0-8°C
IUPAC Name 2-[2-[carboxymethyl-[(2-hydroxyphenyl)methyl]amino]ethyl-[(2-hydroxyphenyl)methyl]amino]acetic acid
InChI InChI=1S/C20H24N2O6/c23-17-7-3-1-5-15(17)11-21(13-19(25)26)9-10-22(14-20(27)28)12-16-6-2-4-8-18(16)24/h1-8,23-24H,9-14H2,(H,25,26)(H,27,28)
InChIKey GRUVVLWKPGIYEG-UHFFFAOYSA-N
SMILES C1=CC=C(C(=C1)CN(CCN(CC2=CC=CC=C2O)CC(=O)O)CC(=O)O)O
Reference

<span style="color:#000000;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:12px;"><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">1. Hershko, C., et al. 1984. J. Lab. Clin. Med. 103: 337-346. PMID: 6699459</span><br style="box-sizing: border-box; color: rgb(51, 51, 51); font-family: openSans, arial, sans-serif; font-size: 14px; font-variant-ligatures: normal; orphans: 2; widows: 2;" />
<span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">2. Rollet-Labelle, E., et al. 1998. Free Radic. Biol. Med. 24: 563-572. PMID: 9559868</span><br style="box-sizing: border-box; color: rgb(51, 51, 51); font-family: openSans, arial, sans-serif; font-size: 14px; font-variant-ligatures: normal; orphans: 2; widows: 2;" />
<span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">3. Gozin, A., et al. 1998. Free Radic. Biol. Med. 25: 1021-1032. PMID: 9870555</span><br style="box-sizing: border-box; color: rgb(51, 51, 51); font-family: openSans, arial, sans-serif; font-size: 14px; font-variant-ligatures: normal; orphans: 2; widows: 2;" />
<span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">4. Faller, B., et al. 2000. J. Med. Chem. 43: 1467-1475. PMID: 10780902</span><br style="box-sizing: border-box; color: rgb(51, 51, 51); font-family: openSans, arial, sans-serif; font-size: 14px; font-variant-ligatures: normal; orphans: 2; widows: 2;" />
<span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">5. Samuni, A.M., et al. 2001. Free Radic. Biol. Med. 30: 170-177. PMID: 11163534</span></span></span></span>

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