N,N′-Disuccinimidyl Carbonate

• CAT Number: R039768
• CAS Number: 74124-79-1
• Molecular Formula: C9H8N2O7
• Molecular Weight: 256.17
• Purity: ≥95%
• Synonyms: 1,1’-[Carbonylbis(oxy)]bis-2,5-pyrrolidinedione;?1-[[[(2,5-Dioxo-1-pyrrolidinyl)oxy]carbonyl]oxy]-2,5-pyrrolidinedione; Bis(2,5-dioxopyrrolidin-1-yl) Carbonate; Bis(N-succinimidyl) Carbonate; Bis(succinimidyl) Carbonate; Carbonic Acid bis(2,5-dioxopy
• Storage: Store at -20°C
• IUPAC Name: bis(2,5-dioxopyrrolidin-1-yl) carbonate
• InChI: InChI=1S/C9H8N2O7/c12-5-1-2-6(13)10(5)17-9(16)18-11-7(14)3-4-8(11)15/h1-4H2
• InChIKey: PFYXSUNOLOJMDX-UHFFFAOYSA-N
• SMILES: C1CC(=O)N(C1=O)OC(=O)ON2C(=O)CCC2=O

N,N′-Disuccinimidyl Carbonate (CAT: R039768) is a highly reactive coupling reagent used primarily for the activation of hydroxyl groups to form carbonate esters and for the synthesis of amine-reactive NHS-carbonates. It facilitates the formation of stable linkages between molecules, making it valuable in the preparation of drug conjugates, bioconjugates, and functionalized polymers. DSC reacts with alcohols to form NHS-carbonates, which can then react with primary amines under mild conditions. This reagent is a white crystalline solid, soluble in organic solvents like DMF or DCM, and is commonly used in peptide synthesis, surface modification, and protein labeling.