For research use only. Not for therapeutic Use.
NMS-E973（Cat No.:R067117）is a potent, selective inhibitor of heat shock protein 90 (HSP90), a molecular chaperone essential for the stability and function of numerous oncogenic client proteins. By binding to HSP90, NMS-E973 promotes degradation of key signaling proteins involved in tumor growth, survival, and metastasis. Preclinical studies show strong anti-tumor activity across multiple cancer models, including breast, lung, and hematologic malignancies. Its favorable pharmacological profile and oral bioavailability support its use in cancer research. NMS-E973 is a promising tool for studying HSP90-targeted therapeutic strategies.
| CAS Number | 1253584-84-7 |
| Synonyms | 5-[2,4-dihydroxy-6-(4-nitrophenoxy)phenyl]-N-(1-methylpiperidin-4-yl)-1,2-oxazole-3-carboxamide |
| Molecular Formula | C22H22N4O7 |
| Purity | ≥95% |
| IUPAC Name | 5-[2,4-dihydroxy-6-(4-nitrophenoxy)phenyl]-N-(1-methylpiperidin-4-yl)-1,2-oxazole-3-carboxamide |
| InChI | InChI=1S/C22H22N4O7/c1-25-8-6-13(7-9-25)23-22(29)17-12-20(33-24-17)21-18(28)10-15(27)11-19(21)32-16-4-2-14(3-5-16)26(30)31/h2-5,10-13,27-28H,6-9H2,1H3,(H,23,29) |
| InChIKey | YLQODGGPIHWTHR-UHFFFAOYSA-N |
| SMILES | CN1CCC(CC1)NC(=O)C2=NOC(=C2)C3=C(C=C(C=C3OC4=CC=C(C=C4)[N+](=O)[O-])O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
