NLS (PKKKRKV) (hydrochloride)

• CAT Number: I044306
• Molecular Formula: C40H79ClN14O8
• Molecular Weight: 919.60
• Purity: ≥95%
• Synonyms: (2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-pyrrolidine-2-carbonyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-methylbutanoic acid;hydrochloride
• InChI: InChI=1S/C40H78N14O8.ClH/c1-25(2)32(39(61)62)54-38(60)30(16-6-10-22-44)52-37(59)31(18-12-24-48-40(45)46)53-36(58)29(15-5-9-21-43)51-35(57)28(14-4-8-20-42)50-34(56)27(13-3-7-19-41)49-33(55)26-17-11-23-47-26;/h25-32,47H,3-24,41-44H2,1-2H3,(H,49,55)(H,50,56)(H,51,57)(H,52,59)(H,53,58)(H,54,60)(H,61,62)(H4,45,46,48);1H/t26-,27-,28-,29-,30-,31-,32-;/m0./s1
• InChIKey: GJEMQFYSOAXAJS-XXZMQFNDSA-N
• SMILES: CC(C)[C@@H](C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1.Cl

NLS (PKKKRKV) (hydrochloride)（Cat No.:I044306）is a synthetic peptide representing the classical nuclear localization signal (NLS) derived from the SV40 large T-antigen. This short, positively charged sequence—Pro-Lys-Lys-Lys-Arg-Lys-Val—is essential for directing proteins to the nucleus by facilitating their recognition and transport through the nuclear pore complex via importin-α/β. The hydrochloride form enhances solubility and stability for laboratory use. Widely used in molecular and cell biology, this NLS peptide aids in the study of nucleocytoplasmic transport, intracellular delivery systems, and nuclear-targeted drug design or gene therapy applications.