NLRP3-IN-10

• CAT Number: I042861
• CAS Number: 2641826-39-1
• Molecular Formula: C17H14BrFO3
• Molecular Weight: 365.19
• Purity: ≥95%
• Synonyms: (E)-3-(4-bromo-2,5-dimethoxyphenyl)-1-(4-fluorophenyl)prop-2-en-1-one
• InChI: InChI=1S/C17H14BrFO3/c1-21-16-10-14(18)17(22-2)9-12(16)5-8-15(20)11-3-6-13(19)7-4-11/h3-10H,1-2H3/b8-5+
• InChIKey: ZXMIFRJYIRYWTC-VMPITWQZSA-N
• SMILES: COC1=CC(=C(C=C1/C=C/C(=O)C2=CC=C(C=C2)F)OC)Br

​NLRP3-IN-10（Cat No.:I042861）is a potent inhibitor of the NLRP3 inflammasome, exhibiting an IC₅₀ of 251.1 nM for inhibiting IL-1β release. It functions by attenuating ASC speck formation, thereby suppressing NLRP3 inflammasome activation. In vitro studies demonstrate that NLRP3-IN-10 effectively inhibits NLRP3 inflammasome activation induced by LPS and MSU in THP-1 cells in a dose-dependent manner. In vivo, a single intravenous dose of 10 mg/kg in an LPS-primed mouse model of MSU-induced peritonitis significantly reduces peritoneal neutrophil influx and IL-1β levels in the spleen. However, oral administration shows low bioavailability and high plasma clearance, indicating challenges for oral dosing.