For research use only. Not for therapeutic Use.
NLRP3/AIM2-IN-3（Cat No.:I045193）is a potent, selective dual inhibitor targeting the NLRP3 and AIM2 inflammasomes, key components of the innate immune system that activate caspase-1, leading to IL-1β and IL-18 maturation and pyroptosis. By blocking both inflammasome pathways, NLRP3/AIM2-IN-3 suppresses excessive inflammation associated with autoimmune, metabolic, and neurodegenerative diseases. It has shown strong activity in preclinical models of gout, atherosclerosis, and Alzheimer’s disease. This compound is a valuable research tool for dissecting inflammasome-mediated signaling and offers therapeutic potential in conditions driven by aberrant innate immune activation while preserving protective host defenses.
| CAS Number | 1787787-60-3 |
| Synonyms | N-(3-hydroxyphenyl)-2-(1H-indol-6-yl)acetamide |
| Molecular Formula | C16H14N2O2 |
| Purity | ≥95% |
| IUPAC Name | N-(3-hydroxyphenyl)-2-(1H-indol-6-yl)acetamide |
| InChI | InChI=1S/C16H14N2O2/c19-14-3-1-2-13(10-14)18-16(20)9-11-4-5-12-6-7-17-15(12)8-11/h1-8,10,17,19H,9H2,(H,18,20) |
| InChIKey | UOBOMCZZCHPHBU-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC(=C1)O)NC(=O)CC2=CC3=C(C=C2)C=CN3 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
