For research use only. Not for therapeutic Use.
NKH477（Cat No.:R028253）is a water-soluble forskolin derivative that directly activates adenylate cyclase, leading to increased intracellular cyclic AMP (cAMP) levels. By elevating cAMP, NKH477 enhances cardiac contractility, vasodilation, and bronchodilation, making it useful for studying cardiovascular and respiratory physiology. It has been investigated as a therapeutic agent for acute heart failure, where it improves myocardial function and circulation without excessive increases in myocardial oxygen consumption. NKH477’s solubility and potent pharmacological profile make it a valuable research compound and potential therapeutic candidate in cardiovascular and pulmonary medicine.
| CAS Number | 138605-00-2 |
| Synonyms | [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-acetyloxy-3-ethenyl-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-6-yl] 3-(dimethylamino)propanoate;hydrochloride |
| Molecular Formula | C27H44ClNO8 |
| Purity | ≥95% |
| IUPAC Name | [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-acetyloxy-3-ethenyl-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-6-yl] 3-(dimethylamino)propanoate;hydrochloride |
| InChI | InChI=1S/C27H43NO8.ClH/c1-10-24(5)15-18(31)27(33)25(6)17(30)11-13-23(3,4)21(25)20(35-19(32)12-14-28(8)9)22(34-16(2)29)26(27,7)36-24;/h10,17,20-22,30,33H,1,11-15H2,2-9H3;1H/t17-,20-,21-,22-,24-,25-,26+,27-;/m0./s1 |
| InChIKey | VIRRLEDAYYYTOD-YHEOSNBFSA-N |
| SMILES | CC(=O)O[C@H]1[C@H]([C@@H]2[C@]([C@H](CCC2(C)C)O)([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)OC(=O)CCN(C)C.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
