For research use only. Not for therapeutic Use.
NJH-2-057 (Cat No.: I045556) is a covalent KEAP1–NRF2 protein–protein interaction inhibitor designed to disrupt KEAP1 binding to NRF2, thereby stabilizing and activating NRF2 signaling. By enhancing NRF2 activity, NJH-2-057 promotes the expression of antioxidant and cytoprotective genes, supporting cellular defense against oxidative stress and electrophilic damage. This compound is widely used in studies of redox biology, cancer, and neurodegenerative diseases, where NRF2 plays a protective role. NJH-2-057 serves as a valuable tool for exploring therapeutic strategies targeting oxidative stress pathways.
| CAS Number | 2858812-70-9 |
| Synonyms | 4-[2-[[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropanecarbonyl]amino]-5-methylpyridin-4-yl]-N-[5-[3-[5-(2-oxo-4-prop-2-enoylpiperazin-1-yl)furan-2-yl]propanoylamino]pentyl]benzamide |
| Molecular Formula | C43H44F2N6O8 |
| Purity | ≥95% |
| InChI | InChI=1S/C43H44F2N6O8/c1-3-37(53)50-21-22-51(38(54)26-50)39-16-13-31(57-39)12-15-36(52)46-19-5-4-6-20-47-40(55)29-9-7-28(8-10-29)32-24-35(48-25-27(32)2)49-41(56)42(17-18-42)30-11-14-33-34(23-30)59-43(44,45)58-33/h3,7-11,13-14,16,23-25H,1,4-6,12,15,17-22,26H2,2H3,(H,46,52)(H,47,55)(H,48,49,56) |
| InChIKey | BFHQYKNPJGDZDF-UHFFFAOYSA-N |
| SMILES | CC1=CN=C(C=C1C2=CC=C(C=C2)C(=O)NCCCCCNC(=O)CCC3=CC=C(O3)N4CCN(CC4=O)C(=O)C=C)NC(=O)C5(CC5)C6=CC7=C(C=C6)OC(O7)(F)F |
| Reference | [1]. Henning NJ, et al. Deubiquitinase-Targeting Chimeras for Targeted Protein Stabilization. 2021 May 03. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
