Nisoxetine hydrochloride（Cat No.:I010357）is a selective norepinephrine reuptake inhibitor (NRI) used primarily in neuroscience research. It blocks the norepinephrine transporter (NET), increasing synaptic concentrations of norepinephrine without significantly affecting dopamine or serotonin uptake. This specificity makes it a valuable tool for studying noradrenergic signaling in mood, attention, and pain modulation. Nisoxetine has been investigated for potential antidepressant activity but is not approved for clinical use. The hydrochloride salt form improves its solubility and handling in laboratory settings. It is commonly used in both in vitro and in vivo neuropharmacological studies.