Nikkomycin Z

• CAT Number: I015021
• CAS Number: 59456-70-1
• Molecular Formula: C₂₀H₂₅N₅O₁₀
• Molecular Weight: 495.44
• Purity: ≥95%
• Target: Fungal
• IUPAC Name: (2S)-2-[[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanoyl]amino]-2-[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]acetic acid
• InChI: InChI=1S/C20H25N5O10/c1-7(13(28)9-3-2-8(26)6-22-9)11(21)17(31)24-12(19(32)33)16-14(29)15(30)18(35-16)25-5-4-10(27)23-20(25)34/h2-7,11-16,18,26,28-30H,21H2,1H3,(H,24,31)(H,32,33)(H,23,27,34)/t7-,11-,12-,13-,14-,15+,16+,18+/m0/s1
• InChIKey: WWJFFVUVFNBJTN-VHDFTHOZSA-N
• SMILES: C[C@H]([C@@H](C1=NC=C(C=C1)O)O)[C@@H](C(=O)N[C@@H]([C@@H]2[C@H]([C@H]([C@@H](O2)N3C=CC(=O)NC3=O)O)O)C(=O)O)N

Nikkomycin Z（Cat No.:I015021）is a potent antifungal agent derived from Streptomyces species, primarily used in the treatment of fungal infections. It inhibits the synthesis of chitin, a key component of fungal cell walls, by targeting chitin synthase. This disruption weakens the fungal cell wall, leading to cell lysis and death. Nikkomycin Z is especially effective against Candida species and certain other pathogenic fungi. It has gained interest in clinical and pharmaceutical research for its potential in treating fungal infections, particularly in immunocompromised patients.

Reference

[1]. R Kovács, et al. Synergistic Effect of Nikkomycin Z With Caspofungin and Micafungin Against Candida Albicans and Candida Parapsilosis Biofilms. Lett Appl Microbiol. 2019 Oct;69(4):271-278.