NiCur

• CAT Number: I044443
• CAS Number: 2674753-39-8
• Molecular Formula: C22H16N2O
• Molecular Weight: 324.38
• Purity: ≥95%
• IUPAC Name: 3-[(E)-[(3E)-3-[(3-cyanophenyl)methylidene]-2-oxocyclohexylidene]methyl]benzonitrile
• InChI: InChI=1S/C22H16N2O/c23-14-18-6-1-4-16(10-18)12-20-8-3-9-21(22(20)25)13-17-5-2-7-19(11-17)15-24/h1-2,4-7,10-13H,3,8-9H2/b20-12+,21-13+
• InChIKey: LENALXRGKSPEKI-ZIOPAAQOSA-N
• SMILES: C1C/C(=C\C2=CC(=CC=C2)C#N)/C(=O)/C(=C/C3=CC(=CC=C3)C#N)/C1

NiCur（Cat No.:I044443）is a small-molecule inhibitor specifically designed to target NIK (NF-κB-inducing kinase), a central component of the non-canonical NF-κB signaling pathway. By inhibiting NIK activity, NiCur suppresses downstream signaling involving p100 processing to p52 and reduces the expression of genes involved in inflammation, immunity, and cell survival. It is particularly valuable in research focused on autoimmune diseases, lymphoid malignancies, and chronic inflammation, where dysregulated NF-κB signaling is implicated. NiCur provides a useful tool for dissecting alternative NF-κB pathway dynamics and developing therapeutic strategies targeting immune and inflammatory disorders.