Niclosamide monohydrate - CAS 73360-56-2
Niclosamide Monohydrate(BAY2353 monohydrate) is used for the treatment of most tapeworm infections by inhibiting DNA replication.
Target: Antiparasitic
Niclosamide (< 5 μM) dose dependently inhibits STAT3-mediated luciferase reporter activity with IC50 of 0.25 μM in HeLa cells. Niclosamide(< 2 μM) dose dependently inhibits the phosphorylation of STAT3 in Du145 cells. Niclosamide (1 μM) inhibits the EGF-induced nuclear translocation of STAT3 in Du145 cells. Niclosamide(< 2 μM) dose dependently inhibits the transcription of STAT3 downstream genes in Du145 cells. Niclosamide(< 10 μM) dose dependently induces G0/G1 arrest and apoptosis of Du145 cancer cells [1]. Niclosamide(< 7.5 μM) promotes Frizzled1 endocytosis, downregulates Dishevelled-2 protein, and inhibits Wnt3A-stimulated beta-catenin stabilization and LEF/TCF reporter activity in U2OS cells [2]. Niclosamide inhibits the TNF-induced NF-κB reporter activity in a dose- and time-dependent manner in U2OS cells. Niclosamide(125 nM) inhibits NF-κB activation induced by p65, IKKα, IKKβ, IKKγ, and TAK1 in U2OS cells. Niclosamide(< 500 nM) completely block the time- and dose-dependent TNFα-induced alteration of the NF-κB-DNA complex in HL-60 cells. Niclosamide(< 10 nM) inhibits constitutive NF-κB activation in U266 cells. Niclosamide inhibits TNF-induced degradation of IκBα and relocation of p65 in a dose- and time-dependent manner in HL-60, Molm13, or AML primary cells. Niclosamide(500 nM) decreases TNF-induced NF-κB-dependent gene products involved in cell survival in HL-60 cells. Niclosamide dose dependently inhibits the growth and induces robust apoptosis of AML cells associated with decreased Mcl-1 and XIAP levels and increased intracellular ROS levels [3].
Catalog Number: I004728
CAS Number: 73360-56-2
PubChem Substance ID:355038597
Molecular Formula: C13H10Cl2N2O5
Molecular Weight:345.13
Purity: ≥95%
* For research use only. Not for human or veterinary use.
Synonym
| Synonyms | 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide;hydrate |
|---|
Property
| Molecular Formula: | C13H10Cl2N2O5 |
|---|---|
| Molecular Weight | 345.13 |
| Target: | Antibiotic |
| Solubility | 10 mM in DMSO |
| Purity | ≥95% |
| Storage | Store at -20C |
Computed Descriptor
| IUPAC Name | 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide;hydrate |
|---|---|
| InChI | InChI=1S/C13H8Cl2N2O4.H2O/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15;/h1-6,18H,(H,16,19);1H2 |
| InChIKey | ZBXRPLQCPHTHLM-UHFFFAOYSA-N |
| SMILES | C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O.O |