For research use only. Not for therapeutic Use.
NHC-triphosphate tetraammonium（Cat No.:I044509）is the triphosphate form of N-hydroxycytidine (NHC), the active antiviral metabolite of molnupiravir, presented as a tetraammonium salt to enhance aqueous solubility and stability. As a nucleoside analog, NHC-triphosphate is incorporated into viral RNA by RNA-dependent RNA polymerases, leading to error-prone replication and ultimately lethal mutagenesis in RNA viruses such as SARS-CoV-2. This compound is instrumental in antiviral mechanism studies, allowing direct examination of RNA chain incorporation and mutation effects. It is widely used in virology and drug development to evaluate nucleotide analog activity and polymerase interactions.
| Synonyms | azane;[[(2R,3S,4R,5R)-3,4-dihydroxy-5-[4-(hydroxyamino)-2-oxopyrimidin-1-yl]oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate |
| Molecular Formula | C9H28N7O15P3 |
| Purity | ≥95% |
| IUPAC Name | azane;[[(2R,3S,4R,5R)-3,4-dihydroxy-5-[4-(hydroxyamino)-2-oxopyrimidin-1-yl]oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate |
| InChI | InChI=1S/C9H16N3O15P3.4H3N/c13-6-4(3-24-29(20,21)27-30(22,23)26-28(17,18)19)25-8(7(6)14)12-2-1-5(11-16)10-9(12)15;;;;/h1-2,4,6-8,13-14,16H,3H2,(H,20,21)(H,22,23)(H,10,11,15)(H2,17,18,19);4*1H3/t4-,6-,7-,8-;;;;/m1..../s1 |
| InChIKey | IZYRQLFDXNWWIS-ODQFIEKDSA-N |
| SMILES | C1=CN(C(=O)N=C1NO)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O.N.N.N.N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
