For research use only. Not for therapeutic Use.
NH-3（Cat No.:I045274）is a selective inhibitor of the acetyltransferase activity of p300/CBP, transcriptional coactivators that regulate gene expression through histone acetylation. By blocking p300/CBP-mediated acetylation of histones and transcription factors, NH-3 alters chromatin structure and suppresses the expression of genes involved in cell growth, differentiation, and survival. This compound is valuable for studying epigenetic regulation, transcriptional control, and oncogenesis, particularly in cancers dependent on p300/CBP activity. Its potency, selectivity, and suitability for biochemical and cell-based assays make NH-3 an important tool for investigating histone acetyltransferase–targeted therapeutic strategies.
| CAS Number | 447415-26-1 |
| Synonyms | 2-[4-[[4-hydroxy-3-[2-(4-nitrophenyl)ethynyl]-5-propan-2-ylphenyl]methyl]-3,5-dimethylphenoxy]acetic acid |
| Molecular Formula | C28H27NO6 |
| Purity | ≥95% |
| IUPAC Name | 2-[4-[[4-hydroxy-3-[2-(4-nitrophenyl)ethynyl]-5-propan-2-ylphenyl]methyl]-3,5-dimethylphenoxy]acetic acid |
| InChI | InChI=1S/C28H27NO6/c1-17(2)25-14-21(15-26-18(3)11-24(12-19(26)4)35-16-27(30)31)13-22(28(25)32)8-5-20-6-9-23(10-7-20)29(33)34/h6-7,9-14,17,32H,15-16H2,1-4H3,(H,30,31) |
| InChIKey | IXMROOKFPWGDGF-UHFFFAOYSA-N |
| SMILES | CC1=CC(=CC(=C1CC2=CC(=C(C(=C2)C(C)C)O)C#CC3=CC=C(C=C3)[N+](=O)[O-])C)OCC(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
