NF157

• CAT Number: M001716
• CAS Number: 104869-26-3
• Molecular Formula: C49H28F2N6Na6O23S6
• Molecular Weight: 1437.10
• Purity: ≥95%
• Synonyms: hexasodium;8-[[4-fluoro-3-[[3-[[3-[[2-fluoro-5-[(4,6,8-trisulfonatonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonate
• InChI: InChI=1S/C49H34F2N6O23S6.6Na/c50-33-9-7-25(47(60)54-35-11-13-39(83(69,70)71)31-19-29(81(63,64)65)21-41(43(31)35)85(75,76)77)17-37(33)56-45(58)23-3-1-5-27(15-23)52-49(62)53-28-6-2-4-24(16-28)46(59)57-38-18-26(8-10-34(38)51)48(61)55-36-12-14-40(84(72,73)74)32-20-30(82(66,67)68)22-42(44(32)36)86(78,79)80;;;;;;/h1-22H,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80);;;;;;/q;6*+1/p-6
• InChIKey: PFKJKZYADCSCBI-UHFFFAOYSA-H
• SMILES: C1=CC(=CC(=C1)NC(=O)NC2=CC=CC(=C2)C(=O)NC3=C(C=CC(=C3)C(=O)NC4=C5C(=CC(=CC5=C(C=C4)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])F)C(=O)NC6=C(C=CC(=C6)C(=O)NC7=C8C(=CC(=CC8=C(C=C7)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])F.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]

NF157(CAT: M001716) is a potent and selective P2Y11 antagonist (pKi 7.35; Ki 44.3 nM) with over 650-fold selectivity against P2Y1 and P2Y2 receptors. It demonstrates IC50 values of 463 nM (P2Y11), 1811 µM (P2Y1), and 170 µM (P2Y2). NF157 reduces metalloproteinase (MMP-3, MMP-13) expression and protects against type II collagen degradation, showing therapeutic potential in osteoarthritis. At 30–60 µM, it restores TNF-α–induced NF-κB activity and p65 nuclear translocation. NF157 exhibits broad receptor selectivity, sparing P2X1 while maintaining inhibitory activity on P2X2, P2X3, P2X4, and P2X7, making it a valuable tool for inflammation and cartilage protection research.