For research use only. Not for therapeutic Use.
Nerigliatin (Cat No.:I008669) is an orally active small-molecule glucokinase activator developed for the treatment of type 2 diabetes mellitus. By enhancing glucokinase activity in pancreatic β-cells and the liver, nerigliatin increases glucose uptake, promotes glycogen synthesis, and stimulates insulin secretion in a glucose-dependent manner. This dual action helps improve glycemic control without causing severe hypoglycemia. Preclinical and clinical studies have shown its potential to lower blood glucose and improve metabolic balance. Nerigliatin remains under investigation as a therapeutic candidate for managing diabetes and related metabolic disorders.
| CAS Number | 1245603-92-2 |
| Synonyms | N,N-dimethyl-5-[[2-methyl-6-[(5-methylpyrazin-2-yl)carbamoyl]-1-benzofuran-4-yl]oxy]pyrimidine-2-carboxamide |
| Molecular Formula | C22H20N6O4 |
| Purity | ≥95% |
| IUPAC Name | N,N-dimethyl-5-[[2-methyl-6-[(5-methylpyrazin-2-yl)carbamoyl]-1-benzofuran-4-yl]oxy]pyrimidine-2-carboxamide |
| InChI | InChI=1S/C22H20N6O4/c1-12-8-24-19(11-23-12)27-21(29)14-6-17-16(5-13(2)31-17)18(7-14)32-15-9-25-20(26-10-15)22(30)28(3)4/h5-11H,1-4H3,(H,24,27,29) |
| InChIKey | MASKQITXHVYVFL-UHFFFAOYSA-N |
| SMILES | CC1=CC2=C(O1)C=C(C=C2OC3=CN=C(N=C3)C(=O)N(C)C)C(=O)NC4=NC=C(N=C4)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
