Neostigmine Bromide

• CAT Number: A000320
• CAS Number: 114-80-7
• Molecular Formula: C12H19N2O2.Br
• Molecular Weight: 303.20
• Purity: ≥95%
• Target: Cholinesterase (ChE)
• Solubility: Limited solubility
• Storage: 3 years -20C powder
• IUPAC Name: [3-(dimethylcarbamoyloxy)phenyl]-trimethylazanium;bromide
• InChI: InChI=1S/C12H19N2O2.BrH/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5;/h6-9H,1-5H3;1H/q+1;/p-1
• InChIKey: LULNWZDBKTWDGK-UHFFFAOYSA-M
• SMILES: CN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C.[Br-]

Neostigmine bromide（Cat No.:A000320）is a quaternary ammonium compound and reversible acetylcholinesterase inhibitor with the molecular formula C12H19BrN2O2. It enhances cholinergic transmission by preventing the breakdown of acetylcholine at neuromuscular junctions, making it useful in treating myasthenia gravis, reversing non-depolarizing neuromuscular blockade, and managing postoperative urinary retention. Due to its charged nature, neostigmine bromide does not cross the blood-brain barrier, limiting its action to peripheral tissues. It is administered orally, intramuscularly, or intravenously. Common side effects include bradycardia, increased salivation, and gastrointestinal upset, requiring careful dosage and monitoring.