Neosaxitoxin

  • CAT Number: T000026
  • CAS Number: 64296-20-4
  • Molecular Formula: C10H17N7O5
  • Molecular Weight: 315.29
  • Purity: ≥95%
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Neosaxitoxin (Cat. No: T000026) is a derivative of tetrahydropurine. Saxitoxin (STX) is one of the main toxins of paralytic shellfish poison (PSP). STX interferes with the conduction process of neuromuscular by blocking Na + channels, so that the random muscles are relaxed and paralyzed, resulting in a series of toxic symptoms.

Catalog Number T000026
CAS Number 64296-20-4
Synonyms

Neosaxitoxin; NeoSTX

Molecular Formula

C10H17N7O5

Purity 95%
Storage 2-8°C
IUPAC Name [(3aS,4R,10aS)-2-amino-5,10,10-trihydroxy-6-imino-3a,4,8,9-tetrahydro-3H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate
InChI InChI=1S/C10H17N7O5/c11-6-14-5-4(3-22-8(13)18)17(21)7(12)16-2-1-9(19,20)10(5,16)15-6/h4-5,12,19-21H,1-3H2,(H2,13,18)(H3,11,14,15)/t4-,5-,10-/m0/s1
InChIKey PPEKGEBBBBNZKS-HGRQIUPRSA-N
SMILES C1CN2C(=N)N(C(C3C2(C1(O)O)N=C(N3)N)COC(=O)N)O
Reference

1: Rodriguez-Navarro AJ, Lagos N, Lagos M, Braghetto I, Csendes A, Hamilton J, Figueroa C, Truan D, Garcia C, Rojas A, Iglesias V, Brunet L, Alvarez F. Neosaxitoxin as a local anesthetic: preliminary observations from a first human trial. Anesthesiology. 2007 Feb;106(2):339-45. PubMed PMID: 17264729.<br />
2: Penzotti JL, Lipkind G, Fozzard HA, Dudley SC Jr. Specific neosaxitoxin interactions with the Na+ channel outer vestibule determined by mutant cycle analysis. Biophys J. 2001 Feb;80(2):698-706. PubMed PMID: 11159437; PubMed Central PMCID: PMC1301268.<br />
3: Hu SL, Kao CY. Interactions of neosaxitoxin with the sodium channel of the frog skeletal muscle fiber. J Gen Physiol. 1991 Mar;97(3):561-78. PubMed PMID: 1645395; PubMed Central PMCID: PMC2216488.

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