Nek2/Hec1-IN-2

• CAT Number: I041079
• CAS Number: 544416-00-4
• Molecular Formula: C16H14N4OS
• Molecular Weight: 310.37
• Purity: ≥95%
• Synonyms: N-[4-(2,4-dimethylphenyl)-1,3-thiazol-2-yl]pyrazine-2-carboxamide
• InChI: InChI=1S/C16H14N4OS/c1-10-3-4-12(11(2)7-10)14-9-22-16(19-14)20-15(21)13-8-17-5-6-18-13/h3-9H,1-2H3,(H,19,20,21)
• InChIKey: GANRESSEAJEWSH-UHFFFAOYSA-N
• SMILES: CC1=CC(=C(C=C1)C2=CSC(=N2)NC(=O)C3=NC=CN=C3)C

Nek2/Hec1-IN-2（Cat No.:I041079）is a small molecule inhibitor targeting the interaction between Nek2 (NIMA-related kinase 2) and Hec1 (highly expressed in cancer 1), two proteins involved in the regulation of cell division and mitosis. By disrupting their interaction, Nek2/Hec1-IN-2 prevents proper spindle assembly and chromosome alignment during mitosis, leading to cell cycle arrest and subsequent apoptosis in cancer cells. This inhibitor has shown potential in preclinical studies for treating various cancers, particularly those with aberrant mitotic regulation, offering a promising therapeutic approach for targeting mitotic dysregulation in tumors.