Ned 19 (CAT: I018520) is a selective antagonist of nicotinic acid adenine dinucleotide phosphate (NAADP) signaling. It acts as a membrane-permeant, non-competitive inhibitor of NAADP, a molecule involved in calcium (Ca2+) signaling. By inhibiting NAADP-mediated Ca2+ signaling, Ned 19 disrupts the release of intracellular Ca2+ stores, which play essential roles in various cellular processes. Ned 19 has been used in research to investigate the specific functions of NAADP signaling and its involvement in cellular responses such as calcium mobilization, vesicle trafficking, and cellular homeostasis.
| Catalog Number | I018520 |
| CAS Number | 874374-25-1 |
| Molecular Formula | C₃₀H₃₁FN₄O₃ |
| Purity | 95% |
| Reference | [1]. Rosen D, et al. Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonistNed-19 indicate two binding sites on the NAADP receptor. J Biol Chem. 2009 Dec 11;284(50):34930-4.<br>[2]. Annarita Favia, et al. NAADP-Dependent Ca2+ Signaling Controls Melanoma Progression, Metastatic Dissemination and Neoangiogenesis. Sci Rep. 2016; 6: 18925. |
