Necrostatin-7

For research use only. Not for therapeutic Use.

  • CAT Number: R046989
  • CAS Number: 351062-08-3
  • Molecular Formula: C16H10FN5OS2
  • Molecular Weight: 371.41
  • Purity: ≥95%
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Necrostatin-7(Cat No.:R046989)is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1), effectively blocking necroptosis—a programmed form of necrotic cell death. By selectively inhibiting RIPK1 activity, Necrostatin-7 suppresses inflammation-driven cellular damage, providing valuable insights into the molecular mechanisms underlying cell death, inflammation, and tissue injury. This compound is especially useful for investigating conditions characterized by pathological necroptosis, including ischemic injuries, neurodegeneration, inflammatory diseases, and autoimmune disorders. Consequently, Necrostatin-7 is widely employed in biomedical research to explore potential therapeutic interventions targeting necroptotic pathways in various chronic and acute disease models.


CAS Number 351062-08-3
Synonyms

(5Z)-5-[[5-(4-fluorophenyl)-1H-pyrazol-4-yl]methylidene]-2-imino-3-(1,3-thiazol-2-yl)-1,3-thiazolidin-4-one

Molecular Formula C16H10FN5OS2
Purity ≥95%
IUPAC Name (5Z)-5-[[5-(4-fluorophenyl)-1H-pyrazol-4-yl]methylidene]-2-imino-3-(1,3-thiazol-2-yl)-1,3-thiazolidin-4-one
InChI InChI=1S/C16H10FN5OS2/c17-11-3-1-9(2-4-11)13-10(8-20-21-13)7-12-14(23)22(15(18)25-12)16-19-5-6-24-16/h1-8,18H,(H,20,21)/b12-7-,18-15?
InChIKey SMJGLNVGTJLIRV-KBEFMPHXSA-N
SMILES C1=CC(=CC=C1C2=C(C=NN2)/C=C\3/C(=O)N(C(=N)S3)C4=NC=CS4)F
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