For research use only. Not for therapeutic Use.
Necrostatin-1 (Nec-1) (inactive control)(CAT: R066923) is an inactive structural analog of Necrostatin-1, a well-characterized inhibitor of necroptosis, a regulated form of necrotic cell death. While Nec-1 selectively targets RIPK1 to block necroptotic signaling, the inactive control variant lacks inhibitory activity, making it an essential negative control for validating the specificity of necroptosis-related assays. This compound is widely used in cell death research to distinguish off-target effects from true RIPK1-dependent necroptosis inhibition. Supplied at high purity, Nec-1 (inactive) is ideal for mechanistic studies, target validation, and the development of RIPK1-targeted therapeutics in inflammation and neurodegeneration research.
| CAS Number | 64419-92-7 |
| Synonyms | 5-(1H-indol-3-ylmethyl)-2-sulfanylideneimidazolidin-4-one |
| Molecular Formula | C12H11N3OS |
| Purity | ≥95% |
| IUPAC Name | 5-(1H-indol-3-ylmethyl)-2-sulfanylideneimidazolidin-4-one |
| InChI | InChI=1S/C12H11N3OS/c16-11-10(14-12(17)15-11)5-7-6-13-9-4-2-1-3-8(7)9/h1-4,6,10,13H,5H2,(H2,14,15,16,17) |
| InChIKey | MPLRRPKKFHUEEL-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C(=C1)C(=CN2)CC3C(=O)NC(=S)N3 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
