Necroptosis-IN-3

• CAT Number: I042468
• CAS Number: 547698-18-0
• Molecular Formula: C12H17NOS
• Molecular Weight: 223.33
• Purity: ≥95%
• Synonyms: N-(thiophen-2-ylmethyl)cyclohexanecarboxamide
• InChI: InChI=1S/C12H17NOS/c14-12(10-5-2-1-3-6-10)13-9-11-7-4-8-15-11/h4,7-8,10H,1-3,5-6,9H2,(H,13,14)
• InChIKey: QTYJPNRSYXQPSF-UHFFFAOYSA-N
• SMILES: C1CCC(CC1)C(=O)NCC2=CC=CS2

Necroptosis-IN-3（Cat No.:I042468）is a small molecule inhibitor designed to target necroptosis, a form of programmed cell death distinct from apoptosis. It specifically inhibits the receptor-interacting protein kinase 1 (RIPK1), a key regulator of necroptosis. By blocking RIPK1 activity, Necroptosis-IN-3 prevents necroptotic cell death, which has been implicated in various diseases such as neurodegenerative disorders, inflammation, and cancer. This inhibitor is being explored in preclinical research to understand its therapeutic potential in conditions where necroptosis contributes to disease progression, offering a novel approach to modulate cell death pathways.