For research use only. Not for therapeutic Use.
NCT-58（Cat No.:I045183）is a potent, selective inhibitor of heat shock protein 90 beta (HSP90β), a molecular chaperone essential for the stability and function of many oncogenic client proteins. By blocking HSP90β activity, NCT-58 promotes the degradation of misfolded or unstable client proteins, thereby suppressing tumor growth and survival. It shows strong efficacy in preclinical models of HER2-positive cancers, including trastuzumab-resistant breast cancer. NCT-58 is a valuable research tool for exploring HSP90β-dependent signaling pathways and holds therapeutic potential in oncology, particularly for overcoming resistance to existing targeted therapies.
| CAS Number | 2411429-33-7 |
| Synonyms | 5-methoxy-N-[3-methoxy-4-(2-piperidin-2-ylethoxy)phenyl]-2,2-dimethylchromene-6-carboxamide |
| Molecular Formula | C27H34N2O5 |
| Purity | ≥95% |
| IUPAC Name | 5-methoxy-N-[3-methoxy-4-(2-piperidin-2-ylethoxy)phenyl]-2,2-dimethylchromene-6-carboxamide |
| InChI | InChI=1S/C27H34N2O5/c1-27(2)14-12-20-22(34-27)11-9-21(25(20)32-4)26(30)29-19-8-10-23(24(17-19)31-3)33-16-13-18-7-5-6-15-28-18/h8-12,14,17-18,28H,5-7,13,15-16H2,1-4H3,(H,29,30) |
| InChIKey | QGEKYFVMAGLOKW-UHFFFAOYSA-N |
| SMILES | CC1(C=CC2=C(O1)C=CC(=C2OC)C(=O)NC3=CC(=C(C=C3)OCCC4CCCCN4)OC)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
