For research use only. Not for therapeutic Use.
NCGC00249987（Cat No.:I015507）is a small-molecule research probe identified through high-throughput screening efforts at the NIH Chemical Genomics Center (NCGC). It has been studied as a selective inhibitor of phosphatidylinositol synthase (PIS), a key enzyme in the biosynthesis of phosphoinositides that regulate membrane dynamics, trafficking, and signaling. By disrupting PIS activity, NCGC00249987 alters lipid metabolism and downstream pathways involved in cell survival, growth, and autophagy. This compound serves as a valuable tool in chemical biology, cancer metabolism, and neurodegeneration research, supporting exploration of lipid-mediated signaling networks and therapeutic opportunities.
| CAS Number | 1384864-80-5 |
| Synonyms | 3-fluoro-N-[(E)-(5-pyrimidin-2-ylsulfanylfuran-2-yl)methylideneamino]benzamide |
| Molecular Formula | C16H11FN4O2S |
| Purity | ≥95% |
| IUPAC Name | 3-fluoro-N-[(E)-(5-pyrimidin-2-ylsulfanylfuran-2-yl)methylideneamino]benzamide |
| InChI | InChI=1S/C16H11FN4O2S/c17-12-4-1-3-11(9-12)15(22)21-20-10-13-5-6-14(23-13)24-16-18-7-2-8-19-16/h1-10H,(H,21,22)/b20-10+ |
| InChIKey | DRXIKWHRYGIZNG-KEBDBYFISA-N |
| SMILES | C1=CC(=CC(=C1)F)C(=O)N/N=C/C2=CC=C(O2)SC3=NC=CC=N3 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
