For research use only. Not for therapeutic Use.
NBI-27914（Cat No.:M035980）is a potent and selective non-peptide antagonist of the angiotensin II type 1 (AT1) receptor, a key component of the renin–angiotensin system (RAS) involved in blood pressure regulation, fluid balance, and cardiovascular function. By blocking AT1 receptor activation, NBI-27914 inhibits the vasoconstrictive and aldosterone-secreting effects of angiotensin II, making it valuable in hypertension and heart failure research. It is commonly used in preclinical models to study cardiovascular pathophysiology, renal function, and inflammatory responses associated with AT1 receptor signaling. NBI-27914 supports the development of novel RAS-targeted therapeutics.
| CAS Number | 184241-44-9 |
| Synonyms | 5-chloro-4-N-(cyclopropylmethyl)-2-methyl-4-N-propyl-6-N-(2,4,6-trichlorophenyl)pyrimidine-4,6-diamine |
| Molecular Formula | C18H20Cl4N4 |
| Purity | ≥95% |
| IUPAC Name | 5-chloro-4-N-(cyclopropylmethyl)-2-methyl-4-N-propyl-6-N-(2,4,6-trichlorophenyl)pyrimidine-4,6-diamine |
| InChI | InChI=1S/C18H20Cl4N4/c1-3-6-26(9-11-4-5-11)18-15(22)17(23-10(2)24-18)25-16-13(20)7-12(19)8-14(16)21/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25) |
| InChIKey | KNADXBVKFAUMCR-UHFFFAOYSA-N |
| SMILES | CCCN(CC1CC1)C2=NC(=NC(=C2Cl)NC3=C(C=C(C=C3Cl)Cl)Cl)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
