For research use only. Not for therapeutic Use.
NBD-14270（Cat No.:I044091）is a potent and selective small-molecule inhibitor targeting the HIV-1 gp120 envelope glycoprotein, a critical component involved in viral entry into host cells. By binding to the CD4-binding site of gp120, NBD-14270 prevents its interaction with the CD4 receptor on T cells, thereby blocking HIV-1 attachment and fusion. This compound is valuable in antiviral drug discovery and HIV research, offering a novel mechanism distinct from reverse transcriptase or protease inhibitors. NBD-14270 is used to explore entry inhibition strategies, helping to advance therapeutic development against drug-resistant HIV-1 strains.
| CAS Number | 2411819-82-2 |
| Synonyms | N-[(1S)-2-amino-1-[5-(hydroxymethyl)-1,3-thiazol-2-yl]ethyl]-3-methyl-5-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrrole-2-carboxamide |
| Molecular Formula | C18H18F3N5O2S |
| Purity | ≥95% |
| IUPAC Name | N-[(1S)-2-amino-1-[5-(hydroxymethyl)-1,3-thiazol-2-yl]ethyl]-3-methyl-5-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrrole-2-carboxamide |
| InChI | InChI=1S/C18H18F3N5O2S/c1-9-4-13(12-3-2-10(6-23-12)18(19,20)21)25-15(9)16(28)26-14(5-22)17-24-7-11(8-27)29-17/h2-4,6-7,14,25,27H,5,8,22H2,1H3,(H,26,28)/t14-/m0/s1 |
| InChIKey | BILBXEUAJZPBIW-AWEZNQCLSA-N |
| SMILES | CC1=C(NC(=C1)C2=NC=C(C=C2)C(F)(F)F)C(=O)N[C@@H](CN)C3=NC=C(S3)CO |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
