For research use only. Not for therapeutic Use.
NBD-14189（Cat No.:I044092）is a potent small-molecule inhibitor that targets the HIV-1 envelope glycoprotein gp120, specifically disrupting its interaction with the CD4 receptor on host T cells. By binding to the CD4-binding pocket, NBD-14189 effectively blocks viral entry and fusion, offering a promising strategy for combating HIV-1 infection, including drug-resistant strains. This entry inhibitor represents a novel class of antiviral agents distinct from traditional reverse transcriptase or protease inhibitors. NBD-14189 is widely used in preclinical HIV research to evaluate gp120-targeted therapies and to support the development of next-generation antiviral strategies.
| CAS Number | 2234273-72-2 |
| Synonyms | N-[(1S)-2-amino-1-[4-(hydroxymethyl)-1,3-thiazol-2-yl]ethyl]-5-[3-fluoro-4-(trifluoromethyl)phenyl]-1H-pyrrole-2-carboxamide |
| Molecular Formula | C18H16F4N4O2S |
| Purity | ≥95% |
| IUPAC Name | N-[(1S)-2-amino-1-[4-(hydroxymethyl)-1,3-thiazol-2-yl]ethyl]-5-[3-fluoro-4-(trifluoromethyl)phenyl]-1H-pyrrole-2-carboxamide |
| InChI | InChI=1S/C18H16F4N4O2S/c19-12-5-9(1-2-11(12)18(20,21)22)13-3-4-14(25-13)16(28)26-15(6-23)17-24-10(7-27)8-29-17/h1-5,8,15,25,27H,6-7,23H2,(H,26,28)/t15-/m0/s1 |
| InChIKey | ZKOITYDZLQYLNI-HNNXBMFYSA-N |
| SMILES | C1=CC(=C(C=C1C2=CC=C(N2)C(=O)N[C@@H](CN)C3=NC(=CS3)CO)F)C(F)(F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
