For research use only. Not for therapeutic Use.
NB-360（Cat No.:I017962）is a potent, orally bioavailable inhibitor of β-secretase 1 (BACE1), a key enzyme involved in the production of β-amyloid peptides that form toxic plaques in Alzheimer’s disease. By selectively blocking BACE1, NB-360 reduces amyloid-β generation, offering a therapeutic strategy to slow or prevent neurodegeneration. It demonstrates strong blood-brain barrier penetration, high selectivity over related aspartyl proteases, and efficacy in reducing amyloid pathology in preclinical models. NB-360 represents a valuable research tool in Alzheimer’s and neurodegenerative disease investigations.
| CAS Number | 1262857-73-7 |
| Synonyms | N-[3-[(3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-2H-1,4-oxazin-3-yl]-4-fluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide |
| Molecular Formula | C21H19F4N5O2 |
| Purity | ≥95% |
| IUPAC Name | N-[3-[(3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-2H-1,4-oxazin-3-yl]-4-fluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide |
| InChI | InChI=1S/C21H19F4N5O2/c1-11-6-12(8-26)9-28-16(11)17(31)29-13-4-5-15(22)14(7-13)19(2)10-32-20(3,18(27)30-19)21(23,24)25/h4-7,9H,10H2,1-3H3,(H2,27,30)(H,29,31)/t19-,20+/m0/s1 |
| InChIKey | BQFHTVUWPJXLOW-VQTJNVASSA-N |
| SMILES | CC1=CC(=CN=C1C(=O)NC2=CC(=C(C=C2)F)[C@@]3(CO[C@@](C(=N3)N)(C)C(F)(F)F)C)C#N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
