For research use only. Not for therapeutic Use.
Naveglitazar（Cat No.:I008245）is a synthetic thiazolidinedione derivative developed as a dual agonist for peroxisome proliferator-activated receptors PPAR-α and PPAR-γ. By activating these nuclear receptors, it modulates lipid and glucose metabolism, improving insulin sensitivity and reducing dyslipidemia. Naveglitazar was investigated as a potential therapeutic for type 2 diabetes and metabolic syndrome, aiming to address both hyperglycemia and cardiovascular risk factors. Although its clinical development was discontinued due to safety concerns, it remains a valuable compound in research exploring PPAR signaling, metabolic regulation, and drug design for diabetes-related disorders.
| CAS Number | 476436-68-7 |
| Synonyms | (2S)-2-methoxy-3-[4-[3-(4-phenoxyphenoxy)propoxy]phenyl]propanoic acid |
| Molecular Formula | C25H26O6 |
| Purity | ≥95% |
| IUPAC Name | (2S)-2-methoxy-3-[4-[3-(4-phenoxyphenoxy)propoxy]phenyl]propanoic acid |
| InChI | InChI=1S/C25H26O6/c1-28-24(25(26)27)18-19-8-10-20(11-9-19)29-16-5-17-30-21-12-14-23(15-13-21)31-22-6-3-2-4-7-22/h2-4,6-15,24H,5,16-18H2,1H3,(H,26,27)/t24-/m0/s1 |
| InChIKey | OKJHGOPITGTTIM-DEOSSOPVSA-N |
| SMILES | CO[C@@H](CC1=CC=C(C=C1)OCCCOC2=CC=C(C=C2)OC3=CC=CC=C3)C(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
