For research use only. Not for therapeutic Use.
Navacaprant (Cat No.:I017961) is a selective κ-opioid receptor (KOR) antagonist under investigation for major depressive disorder (MDD) and bipolar depression. It exhibits high affinity (IC₅₀ ≈ 0.8 nM for KOR) with much lower potency at μ and δ opioid receptors (IC₅₀ ≈ 110 and 6500 nM, respectively). Orally bioavailable, it penetrates the CNS and shows favorable pharmacokinetics in rodents. Phase 2 trials reported antidepressant and anhedonia improvements versus placebo. However, a Phase 3 trial recently failed to meet its primary endpoint.
| CAS Number | 2244614-14-8 |
| Synonyms | 1-[6-ethyl-8-fluoro-4-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl]-N-(oxan-4-yl)piperidin-4-amine |
| Molecular Formula | C25H32FN5O2 |
| Purity | ≥95% |
| IUPAC Name | 1-[6-ethyl-8-fluoro-4-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl]-N-(oxan-4-yl)piperidin-4-amine |
| InChI | InChI=1S/C25H32FN5O2/c1-4-17-13-20-15(2)22(25-27-16(3)30-33-25)24(29-23(20)21(26)14-17)31-9-5-18(6-10-31)28-19-7-11-32-12-8-19/h13-14,18-19,28H,4-12H2,1-3H3 |
| InChIKey | CQOJHAJWCDJEAT-UHFFFAOYSA-N |
| SMILES | CCC1=CC2=C(C(=C(N=C2C(=C1)F)N3CCC(CC3)NC4CCOCC4)C5=NC(=NO5)C)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
