Navacaprant

For research use only. Not for therapeutic Use.

  • CAT Number: I017961
  • CAS Number: 2244614-14-8
  • Molecular Formula: C25H32FN5O2
  • Molecular Weight: 453.55
  • Purity: ≥95%
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Navacaprant (Cat No.:I017961) is a selective κ-opioid receptor (KOR) antagonist under investigation for major depressive disorder (MDD) and bipolar depression. It exhibits high affinity (IC₅₀ ≈ 0.8 nM for KOR) with much lower potency at μ and δ opioid receptors (IC₅₀ ≈ 110 and 6500 nM, respectively). Orally bioavailable, it penetrates the CNS and shows favorable pharmacokinetics in rodents. Phase 2 trials reported antidepressant and anhedonia improvements versus placebo. However, a Phase 3 trial recently failed to meet its primary endpoint.


CAS Number 2244614-14-8
Synonyms

1-[6-ethyl-8-fluoro-4-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl]-N-(oxan-4-yl)piperidin-4-amine

Molecular Formula C25H32FN5O2
Purity ≥95%
IUPAC Name 1-[6-ethyl-8-fluoro-4-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl]-N-(oxan-4-yl)piperidin-4-amine
InChI InChI=1S/C25H32FN5O2/c1-4-17-13-20-15(2)22(25-27-16(3)30-33-25)24(29-23(20)21(26)14-17)31-9-5-18(6-10-31)28-19-7-11-32-12-8-19/h13-14,18-19,28H,4-12H2,1-3H3
InChIKey CQOJHAJWCDJEAT-UHFFFAOYSA-N
SMILES CCC1=CC2=C(C(=C(N=C2C(=C1)F)N3CCC(CC3)NC4CCOCC4)C5=NC(=NO5)C)C
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