For research use only. Not for therapeutic Use.
Narmafotinib (Cat No.:I045078) is an orally bioavailable, selective epidermal growth factor receptor (EGFR) inhibitor designed to target EGFR mutations in non-small cell lung cancer (NSCLC). It is particularly effective against activating mutations like exon 19 deletions and L858R, which drive tumor growth. Narmafotinib inhibits EGFR tyrosine kinase activity, blocking downstream signaling pathways involved in cell proliferation and survival. Preclinical studies show potent antitumor activity and favorable pharmacokinetics. Its selectivity and tolerability position narmafotinib as a promising candidate for treating EGFR-mutant NSCLC.
| CAS Number | 1393653-34-3 |
| Synonyms | 2-[2-[2-[2-[2-methoxy-4-(1-methylpiperidin-4-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]acetamide |
| Molecular Formula | C28H32F3N5O2 |
| Purity | ≥95% |
| IUPAC Name | 2-[2-[2-[2-[2-methoxy-4-(1-methylpiperidin-4-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]acetamide |
| InChI | InChI=1S/C28H32F3N5O2/c1-36-13-11-19(12-14-36)21-8-10-24(25(15-21)38-2)35-27-33-17-22(28(29,30)31)23(34-27)9-7-18-5-3-4-6-20(18)16-26(32)37/h3-6,8,10,15,17,19H,7,9,11-14,16H2,1-2H3,(H2,32,37)(H,33,34,35) |
| InChIKey | AWJVIOYPZZZYAX-UHFFFAOYSA-N |
| SMILES | CN1CCC(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)CCC4=CC=CC=C4CC(=O)N)C(F)(F)F)OC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
