Nampt-IN-5

• CAT Number: I016960
• CAS Number: 2380013-17-0
• Molecular Formula: C25H25N5O2
• Molecular Weight: 427.50
• Purity: ≥95%
• Synonyms: N-[4-[(2-ethoxybenzimidazol-1-yl)methyl]phenyl]-3-pyridin-3-ylazetidine-1-carboxamide
• InChI: InChI=1S/C25H25N5O2/c1-2-32-25-28-22-7-3-4-8-23(22)30(25)15-18-9-11-21(12-10-18)27-24(31)29-16-20(17-29)19-6-5-13-26-14-19/h3-14,20H,2,15-17H2,1H3,(H,27,31)
• InChIKey: JWEBCHOGBDMGBY-UHFFFAOYSA-N
• SMILES: CCOC1=NC2=CC=CC=C2N1CC3=CC=C(C=C3)NC(=O)N4CC(C4)C5=CN=CC=C5

Nampt-IN-5 (CAT: I016960) is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor, demonstrating strong antiproliferative activity with cellular IC₅₀ values of 0.7 nM and 3.9 nM in A2780 and COR-L23 cancer cells, respectively. It also inhibits CYP3A4 activity (IC₅₀ = 0.75 μM). Pharmacological profiling shows favorable ADME properties, including mouse microsomal clearance (110 μL/min·mg), solubility at pH 6.8 (0.056 mM), and MDCK Papp AB (18.6). In mice, oral dosing (10 mg/kg) yields T₁/₂ of 2.1 h, Cmax of 29,112 nM, and AUC of 61,984 nM·h. Nampt-IN-5 is a valuable tool for cancer metabolism and NAD⁺ biosynthesis research.