Nalpha-Fmoc-Ndelta-trityl-L-glutamine

• CAT Number: M118080
• CAS Number: 132327-80-1
• Molecular Formula: C39H34N2O5
• Molecular Weight: 610.71
• Purity: ≥95%
• Storage: Store at RT
• IUPAC Name: (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-5-oxo-5-(tritylamino)pentanoic acid
• InChI: InChI=1S/C39H34N2O5/c42-36(41-39(27-14-4-1-5-15-27,28-16-6-2-7-17-28)29-18-8-3-9-19-29)25-24-35(37(43)44)40-38(45)46-26-34-32-22-12-10-20-30(32)31-21-11-13-23-33(31)34/h1-23,34-35H,24-26H2,(H,40,45)(H,41,42)(H,43,44)/t35-/m0/s1
• InChIKey: WDGICUODAOGOMO-DHUJRADRSA-N
• SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)NC(=O)CCC(C(=O)O)NC(=O)OCC4C5=CC=CC=C5C6=CC=CC=C46

Nα-Fmoc-Nδ-trityl-L-glutamine(CAT: M118080) is a doubly protected L-glutamine derivative with the molecular formula C₃₅H₃₂N₂O₅, designed for use in solid-phase peptide synthesis (SPPS). The α-amino group is protected with a fluorenylmethyloxycarbonyl (Fmoc) group, while the δ-amide side chain is protected with a bulky trityl (triphenylmethyl) group to prevent side reactions during chain assembly. It appears as a white to off-white crystalline powder, sparingly soluble in water but soluble in organic solvents such as DMF and DCM. This orthogonal protection strategy allows for precise incorporation of glutamine residues into peptides, facilitating the synthesis of high-purity bioactive peptides and complex peptide-based therapeutics.