For research use only. Not for therapeutic Use.
Naloxone HCl (CAT: A000537) is an opioid receptor antagonist widely used to reverse the effects of opioid overdose, including respiratory depression, sedation, and hypotension. It appears as a white to off-white crystalline powder, freely soluble in water, and is typically administered via intravenous, intramuscular, subcutaneous, or intranasal routes. Naloxone binds competitively to μ-, κ-, and δ-opioid receptors, displacing opioid molecules without activating the receptors, thereby rapidly restoring normal breathing in cases of opioid toxicity. It has a rapid onset but relatively short duration of action, often requiring repeat dosing. In research, it is also used to study opioid signaling and receptor pharmacology.
| CAS Number | 357-08-4 |
| Synonyms | Naloxone hydrochloride; Naloxone HCl; 357-08-4; Evzio; NIH 7890; EN-15304; KLOXXADO; REZENOPY |
| Molecular Formula | C19H21NO4 • HCl |
| Purity | ≥95% |
| Target | Opioid receptor |
| Storage | 3 years -20C powder |
| IUPAC Name | (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;hydrochloride |
| InChI | InChI=1S/C19H21NO4.ClH/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;/h2-4,14,17,21,23H,1,5-10H2;1H/t14-,17+,18+,19-;/m1./s1 |
| InChIKey | RGPDIGOSVORSAK-STHHAXOLSA-N |
| SMILES | C=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
