nAChR agonist 1

• CAT Number: I016918
• CAS Number: 1394371-75-5
• Molecular Formula: C20H18ClNO3S2
• Molecular Weight: 419.94
• Purity: ≥95%
• Synonyms: 4-[5-(4-chlorophenyl)-4-methyl-2-propanoylthiophen-3-yl]benzenesulfonamide
• InChI: InChI=1S/C20H18ClNO3S2/c1-3-17(23)20-18(13-6-10-16(11-7-13)27(22,24)25)12(2)19(26-20)14-4-8-15(21)9-5-14/h4-11H,3H2,1-2H3,(H2,22,24,25)
• InChIKey: DYIIYIJHDMIABW-UHFFFAOYSA-N
• SMILES: CCC(=O)C1=C(C(=C(S1)C2=CC=C(C=C2)Cl)C)C3=CC=C(C=C3)S(=O)(=O)N

nAChR Agonist 1 (CAT: I016918) is a potent, brain-permeable, and orally efficacious positive allosteric modulator of α7 nicotinic acetylcholine receptors (α7 nAChR). In Ca²⁺ mobilization assays using IMR-32 neuroblastoma cells, it shows an EC₅₀ of 0.32 μM (PNU-282987-induced, FLIPR-based). In vivo, acute oral dosing (1–3 mg/kg) significantly enhances memory acquisition and consolidation in rat cognitive models, including time-delay and scopolamine-induced amnesia. Pharmacokinetics reveal oral bioavailability (F) of 63%, with Cmax = 2.3 μM and AUC = 63 h·μM at 10 mg/kg. By enhancing α7 nAChR signaling, this compound represents a promising therapeutic lead for Alzheimer’s disease.