N-Octylmaleimide

• CAT Number: R002892
• CAS Number: 4080-76-6
• Molecular Formula: C12H19NO2
• Molecular Weight: 209.28
• Purity: ≥95%
• Synonyms: 1-octylpyrrole-2,5-dione
• InChI: InChI=1S/C12H19NO2/c1-2-3-4-5-6-7-10-13-11(14)8-9-12(13)15/h8-9H,2-7,10H2,1H3
• InChIKey: KIKBJYQCJJXCBZ-UHFFFAOYSA-N
• SMILES: CCCCCCCCN1C(=O)C=CC1=O

N-Octylmaleimide (Cat No.: R002892) is a synthetic maleimide derivative commonly used as a biochemical reagent for studying thiol modification and protein function. It selectively reacts with cysteine residues in proteins, enabling the investigation of redox regulation, enzyme activity, and structural dynamics. With its hydrophobic octyl chain, N-Octylmaleimide can also modulate membrane-associated protein interactions, making it useful in membrane biochemistry and signaling research. This compound is widely applied in protein chemistry, enzymology, and drug discovery as a tool for probing thiol-dependent biological processes.

Reference

[1]. B Vakili, M Banner, et al. Inhibition of rat liver glucose 6-phosphatase by N-alkylmaleimides. Biochem Soc Trans. 1979 Feb;7(1):168-70.
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