N-Fmoc-2,5-difluoro-L-phenylalanine

• CAT Number: L013345
• CAS Number: 1004959-90-3
• Molecular Formula: C24H19F2NO4
• Molecular Weight: 423.4
• Purity: ≥95%
• IUPAC Name: (2S)-3-(2,5-difluorophenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid
• InChI: InChI=1S/C24H19F2NO4/c25-15-9-10-21(26)14(11-15)12-22(23(28)29)27-24(30)31-13-20-18-7-3-1-5-16(18)17-6-2-4-8-19(17)20/h1-11,20,22H,12-13H2,(H,27,30)(H,28,29)/t22-/m0/s1
• InChIKey: VLGUITFILRLIFL-QFIPXVFZSA-N
• SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)N[C@@H](CC4=C(C=CC(=C4)F)F)C(=O)O

N-Fmoc-2,5-difluoro-L-phenylalanine(CAT: L013345) is a fluorinated, Fmoc-protected amino acid derivative tailored for solid-phase peptide synthesis (SPPS). Featuring fluorine substitutions at the 2- and 5-positions of the aromatic ring, this modified L-phenylalanine offers enhanced electronic and steric properties that influence peptide conformation, stability, and biological activity. The Fmoc group ensures compatibility with standard Fmoc/t-Bu SPPS protocols, making it ideal for site-specific incorporation into peptides and peptidomimetics.